D Throat Spray Mechanism of Action

Pharmacology: Pharmacodynamics: Mechanism of action: Benzydamine hydrochloride is a nonsteroidal anti-inflammatory drug (NSAID) but it differs chemically from other NSAIDs in that it is a base rather than an acid. Benzydamine reduces local pain and inflammation by inhibiting prostaglandin synthesis which does not interfere with arachidonic acid metabolism, and stabilizing the cellular membrane, inhibition of granuloma formation as demonstrated by the inhibition of granule release from neutrophils and the stabilization of lysosomes. At concentrations used for topical treatment, benzydamine possesses local anaesthetic action. The local anesthetic activity of this compound has been related to an interaction with cationic channels.
The relation of dose and pharmacodynamic responses: No information.
Mechanism of toxicity: No information.
Pharmacokinetics: Absorption: Benzydamine hydrochloride is well absorbed into the oral mucosa. Following oral administration, benzydamine is rapidly absorbed from the gastrointestinal tract and maximum plasma levels reached after 2-4 hours.
Distribution: The most important aspect of the tissue distribution of benzydamine is its tendency to concentrate at the site of inflammation. After intravenous or intramuscular injection in dairy cows, benzydamine was rapidly transferred to milk.
Metabolism and elimination: About half of the benzydamine is excreted unchanged via the kidney at a rate of 10% of the dose within the first 24 hours. The remainder is metabolised, mostly to N-Oxide.
Toxicology: Preclinical safety data: There are no available for preclinical safety data.